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NameMarcelo M. Nociari
DesignationAssistant Professor
DepartmentOphthalmology
CountryUSA
Address

Weill cornell Medicine, Dyson Research Institute, Ophthalmology, 13oo York Avenue, Room E311C, New York, 10065.


Biography :

Personal Statement

My lab in the Department of Ophthalmology at WCMC is studying retinal degeneration associated with the accumulation of lipofuscin in the Retinal Pigment Epithelium (RPE). Currently we are focusing on two lines of translational research: (i) To develope a pharmacological approach to clear lipofuscin buildups from RPE; (ii) To identify and target lipofuscin toxic cascades to prevent RPE malfunction.

Positions and Honors
Positions and Employment

1989-92 Graduate student fellowship from the National Research Council (CONICET), of Argentina.
1992-96 Research Fellow, Department of Microbiology, School of Medicine, UBA.
1993 International Fellowship, Brazilian Center for Biotechnology.
1992-96 Teaching Assistant, Department of Biochemistry, University of Buenos Aires.
1993. Advances in Epidemiology of Hospital Infections, Florencio Fiorini Award.
1997-00 Postdoctoral fellow, Immunobiology of Aging Laboratory, Weill Cornell Medical College (WCMC), New York.
2000-04 Postdoctoral Associate. Department of Medicine, Division of International Medicine and Infectious Diseases, WCMC, New York.
2004-09 Instructor in Immunology (Mentor: Dr. Falck Pedersen), Microbiology, WCMC.
2009-10 Assistant Research Professor. (Mentor: Ronald Crystal) WCMC, New York.
2010-15 Assistant Research Professor. Ophthalmology. WCMC, New York.
2015- Assistant Professor. Department of Ophthalmology. WCMC, New York.

Ad hoc reviewer International Journal of Molecular Sciences, Human Immunology; Journal of Immunological Methods; Scientific Reports; Pharmaceutical and Biomedical Analysis. Member of the Editorial Board of the Ophthalmology Open Journal (OOJ) .

 

Research :

  • 1. As a graduate student, I developed genetic methods to genotype bacteria as a screen for nosocomial infections.
  • Nociari MM, Catalano M, Torrero M, Sordelli DO. Pseudomonas aeruginosa ribotyping: stability and interpretation of ribosomal operon restriction patterns. Diagn Microbiol Infect Dis. 1996 May;25(1):27-33.PMID:8831042
  • Nociari MM, Catalano M, Centrón García D, Copenhaver SC, Vasil ML, Sordelli DO. Diagn Microbiol Infect Dis. 1996 Apr;24(4):179-90. Comparative usefulness of ribotyping, exotoxin A genotyping, and SalI restriction fragment length polymorphism analysis for Pseudomonas aeruginosa lineage assessment.PMID:8831031
  • 2. As a postdoctoral fellow, I combined studies in immunology and aging.
  • Nociari, M.M., W. Telford, and C. Russo, Post-thymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype. J.Immunol, 1999. 162(6): 3327-35
  • Fontan, P.A., V. Pancholi, M.M. Nociari, and V.A. Fischetti, Antibodies to streptococcal surface enolase react with human alpha-enolase: implications in poststreptococcal sequelae. J Infect Dis, 2000. 182(6): p. 1712-21.
  • Moldenhauer, A., M. Nociari, G. Lam, A. Salama, S. Rafii, and M.A. Moore, Tumor necrosis factor alpha-stimulated endothelium: an inducer of dendritic cell development from hematopoietic progenitors and myeloid leukemic cells. Stem Cells, 2004. 22(2): p. 144-57.
  • Almeida, A.S., P.M. Lago, N. Boechat, R.C. Huard, L.C. Lazzarini, A.R. Santos, Nociari M., H. Zhu, B.M. Perez-Sweeney, H. Bang, Q. Ni, J. Huang, A.L. Gibson, V.C. Flores, L.R. Pecanha, A.L. Kritski, J.R. Lapa e Silva, and J.L. Ho, Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity. J Immunol, 2009. 183(1): p. 718-31.
  • 3. With the support of a KO1 Minority Award, with the supervision of Dr. Erik Falck-Pedersen, we worked to identify innate immune pathways implicated in the recognition of adenoviruses.
  • Nociari, M., O. Ocheretina, M. Murphy, and E. Falck-Pedersen. Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling. J Virol, 2009. 83(9): p. 4081-91. PMCID: PMC2668477.
  • Nociari, M., O. Ocheretina, J.W. Schoggins, and E. Falck-Pedersen, Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator. J Virol, 2007. 81(8): p. 4145-57.PMCID: PMC1866159.
  • Schoggins, J.W., M. Nociari, N. Philpott, and E. Falck-Pedersen, Influence of fiber detargeting on adenovirus-mediated innate and adaptive immune activation. J Virol, 2005. 79(18): p. 11627-37.PMCID:PMC1212603.
  • Philpott, N.J., M. Nociari, K.B. Elkon, and E. Falck-Pedersen, Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway. Proc Natl Acad Sci U S A, 2004. 101(16): p. 6200-5.PMCID: PMC395946.
  • 4. Lipofuscin and Retinal Degeneration. For the past six years, I have been working on the development of a pharmacological approach for the treatment of lipofuscin-elicited retinal diseases. Patent: Cyclic Oligosaccharides and Their Use as Lipofuscin Chelators. M. Nociari, E. Rodriguez-Boulan. Published on 2/6/2014. Publication number US-2014-0038918-A
  • Nociari, M.M., A. Shalev, P. Benias, and C. Russo, A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J Immunol Methods, 1998.              213(2): p. 157-67.
  • Nociari M.M., Lehmann G., Perez Bay A., Radu R., Jiang Z, Goicochea S., Schreiner R., Warren J.D., Shan J., Beaumais S., Ménand M., Sollogoub M., Maxfield F. and Rodriguez-Boulan E. Beta cyclodextrins bind, stabilize and remove lipofuscin bisretinoids from retinal pigment epithelium. Proc Natl Acad Sci U S A, 2014. 111(14), pp.E1402–8.
  • Nociari M.M, S. Kiss, E. Rodriguez-Boulan, Lipofuscin Accumulation into and Clearance from Retinal Pigment Epithelium Lysosomes: Physiopathology and Emerging Therapeutics, in: P.D. Sharma (Ed.), Lysosomes - Assoc. Dis. Methods to Study Their Funct., InTech, Rijeka, 2017. doi:10.5772/intechopen.69304.

 

Education:

  • School of Chemistry, Buenos Aires, Bachelor, 12/87, Chemistry.
  • University of Buenos Aires School of Biochemistry, Master, 12/92, Biochemistry.
  • University of Buenos Aires Medical School, PhD, 1/97, Bacterial Genotyping.
  • National Research Council, Buenos Aires, Grad.Student, 1992-7, Microbiology.
  • Weill Medical College of Cornell University, Post-doc, 1997-00, Immuno-Senescence.
  • Weill Medical College of Cornell University, Post-doc, 2000-04, Innate Immunity.

Research Interests:

Research Support

Ongoing projects

• NIH/NEI R01 EY027422. Marcelo M. Nociari (PI). 2017-22. Title: Modulation of Lipid Bisretinoids Clearance with Beta-Cyclodextrins. This proposal aimed to study the molecular mechanisms of CD-mediated removal of lipofuscin bisretinoids (LBs) from RPE, and develop nanoparticles for increased effiency of delivery of CDs into RPE lysosomes.

•BrightFocus Foundation. M. Nociari (PI), 2016-8. Title: Lipofuscin-mediated ER stress in the pathogenesis of macular degeneration. The goals of this project is to characterize the toxic cascades activated by lipid-bisretinoid rich lipofuscin deposits in RPE cells of the retina and identify pharmacological targets within these pathways that can halt retina degeneration.

List of Publications:

1. Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.
Nociari MM, Lehmann GL, Perez Bay AE, Radu RA, Jiang Z, Goicochea S, Schreiner R, Warren JD, Shan J, Adam de Beaumais S, Ménand M, Sollogoub M, Maxfield FR, Rodriguez-Boulan E.
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1402-8. doi: 10.1073/pnas.1400530111. Epub 2014 Mar 24.
PMID: 24706818 Free PMC Article
Select item 19535630

2. Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity.
Almeida AS, Lago PM, Boechat N, Huard RC, Lazzarini LC, Santos AR, Nociari M, Zhu H, Perez-Sweeney BM, Bang H, Ni Q, Huang J, Gibson AL, Flores VC, Pecanha LR, Kritski AL, Lapa e Silva JR, Ho JL.
J Immunol. 2009 Jul 1;183(1):718-31. doi: 10.4049/jimmunol.0801212. Epub 2009 Jun 17.
PMID: 19535630 Free Article
Select item 19211767

3. Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling.
Nociari M, Ocheretina O, Murphy M, Falck-Pedersen E.
J Virol. 2009 May;83(9):4081-91. doi: 10.1128/JVI.02591-08. Epub 2009 Feb 11.
PMID: 19211767 Free PMC Article
Select item 17251283

4. Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator.
Nociari M, Ocheretina O, Schoggins JW, Falck-Pedersen E.
J Virol. 2007 Apr;81(8):4145-57. Epub 2007 Jan 24.
PMID: 17251283 Free PMC Article
Select item 16140740

5. Influence of fiber detargeting on adenovirus-mediated innate and adaptive immune activation.
Schoggins JW, Nociari M, Philpott N, Falck-Pedersen E.
J Virol. 2005 Sep;79(18):11627-37.
PMID: 16140740 Free PMC Article
Select item 15071185

6. Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway.
Philpott NJ, Nociari M, Elkon KB, Falck-Pedersen E.
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6200-5. Epub 2004 Apr
PMID: 15071185 Free PMC Article
Select item 14990854

7. Tumor necrosis factor alpha-stimulated endothelium: an inducer of dendritic cell development from hematopoietic progenitors and myeloid leukemic cells.
Moldenhauer A, Nociari M, Lam G, Salama A, Rafii S, Moore MA.
Stem Cells. 2004;22(2):144-57.
PMID: 14990854 Free Article
Select item 12670372

8. Optimized culture conditions for the generation of dendritic cells from peripheral blood monocytes.
Moldenhauer A, Nociari MM, Dias S, Lalezari P, Moore MA.
Vox Sang. 2003 Apr;84(3):228-36.
PMID: 12670372
Select item 11069244

9. Antibodies to streptococcal surface enolase react with human alpha-enolase: implications in poststreptococcal sequelae.
Fontán PA, Pancholi V, Nociari MM, Fischetti VA.
J Infect Dis. 2000 Dec;182(6):1712-21. Epub 2000 Nov 8.
PMID: 11069244
Select item 10092786

10. Postthymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype.
Nociari MM, Telford W, Russo C.
J Immunol. 1999 Mar 15;162(6):3327-35.
PMID: 10092786 Free Article
Select item 9692848

11. A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity.
Nociari MM, Shalev A, Benias P, Russo C.
J Immunol Methods. 1998 Apr 15;213(2):157-67.
PMID: 9692848
Select item 8910756

12. The use of plasmid profile analysis and ribotyping for typing Acinetobacter baumannii isolates.
García DC, Nociari MM, Sordelli DO, Di Martino A, Catalano M.
J Hosp Infect. 1996 Oct;34(2):139-44.
PMID: 8910756
Select item 8831042

13. Pseudomonas aeruginosa ribotyping: stability and interpretation of ribosomal operon restriction patterns.
Nociari MM, Catalano M, Torrero M, Sordelli DO.
Diagn Microbiol Infect Dis. 1996 May;25(1):27-33.
PMID: 8831042
Select item 8831031

14. Comparative usefulness of ribotyping, exotoxin A genotyping, and SalI restriction fragment length polymorphism analysis for Pseudomonas aeruginosa lineage assessment.
Nociari MM, Catalano M, Centrón García D, Copenhaver SC, Vasil ML, Sordelli DO.
Diagn Microbiol Infect Dis. 1996 Apr;24(4):179-90.
PMID: 8831031
Select item 8600321

15. Neutrophil apoptosis induced by proteolytic enzymes.
Trevani AS, Andonegui G, Giordano M, Nociari M, Fontán P, Dran G, Geffner JR.
Lab Invest. 1996 Mar;74(3):711-21.
PMID: 8600321
Select item 7546648

16. Tumor necrosis factor alpha plus interleukin 1 beta treatment protects granulocytopenic mice from Pseudomonas aeruginosa lung infection: role of an unusual inflammatory response.
Amura CR, Fontan PA, Sanjuan N, Nociari MM, Buzzola FR, Sordelli DO.
APMIS. 1995 Jun;103(6):447-59.
PMID: 7546648

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